Phentermine acts by stimulating the hypothalamus gland of the brain and affecting certain neurotransmitters. Neuro transmitters are certain kind of chemicals in the brain with which the brain cells communicate with each other. It is the hypothalamus gland of the brain which controls certain things in a man for e. Phentermine resin became available in the United States in and Phentermine Hydrochloride in the early s. Phentermine first received approval from the Food and Drug Administration FDA in as an appetite suppressant for the short-term treatment of obesy.
Most patients who consumed fenfluramine complained of effects such as anxiety and nausea on a large scale basis. American Home Products manufactured the drug under the name Pondimin, but the market sales were extremely poor and it never caught on as a suitable alternative to regular exercise and dieting. In , researchers at the University of Rochestor stated that the combination of phentermine and fenfluramine was incredibly effective as an obesity combatant.
The research team, led by Dr. Micheal Weintraub, believed that this combination did not cause the same irritating side effects that other diet drugs did. This led to a huge surge in the popularity and sales of phentermine. Fen-Phen was highly successful in the market as there were cases in which patients were able to drop as much as 30 pounds in a couple of months.
As the popularity of Fen-Phen soared, American Home Products was worried as the patent the company held for Pondimin was about to expire. The company was against the idea of its competitors getting their hands on fenfluramine and the burgeoning profits of Fen-Phen.
American Home Products had to find a solution to this problem before their market share dipped. This problem was solved by the introduction of Redux to the market. American Home Products and its subsidiaries developed a brand new version of fenfluramine, which happened to be known as dexfenfluramine.
The FDA was particularly wary about this new weight loss drug, but it approved the drug in after intensive debates about its potentially harmful effects. The introduction of Dexfen-Phen reinvigorated the market, and it was thought to be even better than Fen-Phen when it came to fighting obesity. Just like the fenfluramine and phentermine combine, Dexfen-Phen was not intensively tested for safety. The company's focus at this time was to ensure that the FDA would approve its new product before the patent on fenfluramine ran out.
As such, it was not highly preoccupied with the adverse effects of dexfenfluramine on the people who consumed it. As the sales of Dexfen-Phen were rising in , multiple reports of its adverse effects and its links to coronary heart disease surfaced and a few patients consuming the medication ended up dead, including some patients who had a history of clean health.
The FDA could no longer sit idle and it banned the commercial distribution of dexfenfluramine and fenfluramine. What are the side effects of phentermine? Phentermine has multiple side effects that have come to the fore in various ways over the years. Phentermine's contentious history has time and again led to numerous experts to call for its removal from the market, but the drug has managed to stay in distribution thanks to a number of factors.
Some of the side effects of phentermine include severe chest pain, decreased energy levels, dizziness and fainting, irregular and rapid heartbeat, swelling and trembling of the feet, thought impairment, headaches, and numbness of the arms and legs.
The effects also include restlessness, euphoria, hypertension, diarrhea, dry mouth, facial oedema, impotence, urticaria, and arrhythmia.
Phentermine has been known to have various gastrointestinal effects on the body. This primarily includes vomiting and cramps. Acute transient ischaemic colitis has also been linked to regular intake of phentermine. The dermatological effects of the drug include pale skin and drying of the mucous membrane.
The drug also has notable genitourinary effects. Acute urinary retention is a common symptom. Renal ischemia is possible, and renal failure can also occur in tandem with dehydration and rhabdomolysis.
Phentermine is also known to have severe effects on the body's endocrine system. Patients who have been consuming phentermine for at least eight weeks have been known to report significant changes in libido in addition to instances of decreased sexual interest and impotence. Geriatric patients have also been known to be more sensitive to phentermine. Geriatric patients should be prescribed very small amounts of phentermine to begin with.
This is because their cardiovascular, renal, endocrine, hepatic, and other functions are likely to be much lower than that of younger adults. The kidneys are known to excrete substantial amounts of phentermine and this is more likely to lead to toxic reactions in geriatric patients, as they are likely to have weaker renal functions.
There are numerous medications that may interact with phentermine and produce harmful side effects. Dexfenfluramine and fenfluramine are primary examples of this problem, having played a great role in causing heart diseases. Substances such as phenelzine and furazolidone are contraindicated because they may lead to elevated blood pressure levels, decreased heart rate, elevated body temperature levels, and even severe lung problems.
Potential to cause heart disease and pulmonary hypertension Cardiovascular diseases associated with phentermine have been suspected since the s. Various causes of palpitations, ischemic events, and tachycardia have been reported. Just curious, I know it's probably highly variable from year to year and given the small number of spots around, but is Med-Psych generally extremely competitive. I firmly believe that anyone with enough practice can get the score that they want to get.
I know this question has been asked in this thread before, but I didn't see a clear cut answer, I don't want to seem like I am padding but I have presented the same poster title at different conferences, some nationally, and some locally, unfortunately, I can't list multiple conferences and locations under the same poster title, would it be okay for me to list each conference separately with their respective dates and locations but with the same poster title.
When I returned to school, my parents welcomed me to move back home but I was too proud, I didn't want to be the 35 year old moving back in with Mom and Dad. There's already an intensivist at said hospital and you're essentially a backup ICU doc to give advice or you're the main intensivist and manage patients through computers and cameras. S, after doing residency in Canada! It's worth investing some effort to figure out which you want to do.
I got my letter Saturday, but I was not expecting anyone getting a decision so soon. Right now, it's pretty much if you want to do research, find a professor in the field of interest and they'll fall over backwards to help you accomplish your goals.
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If something's over your head, you should be referring to physicians. You do know, don't you, that "notorious" means famous or well known for some BAD behavior or reason. A nursing degree allows for a considerable amount of latitude, it's not just floor nursing. It depends on the condition of every individual of how the tablet reacts. You can have mild, moderate and even severe side effects and it depends on how much your body can take.
If you are unable to face these circumstances, you should discontinue the medicine or consult your doctor to see if this medicine is suiting you or not. Take instructions from your doctor at every step of this task.
He upped my dose to I have so much trouble sleeping at night and it almost feels like my mind is running but my body has no desire to move. I almost feel depressed. I have only lost 6lbs but I have been working out alot. I decided to take half the pill to see if that would be better and it seemed better at first but still have trouble sleeping. Maybe it is just me Ashli Hey Kris, My doctor prescribed me a 30 mg dose. Stephen Editor Hey, DJ! Are you on any other stimulants?
I'll use it as a last resort. Thanks for all the advice and encouragement this site has. Being so grossly overweight has ruined a large part of my life as well as the fact that trying WW, JC, Sbeach, Atkins, etc. Now, this is my last resort before considering surgery.
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